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Pharmaceutical Development Problems We Solve

We specialize in ophthalmic and injectable drug development problems. Our agile and integrated approach ensures you get groundbreaking solutions at the speed you need.

Whether implementing existing technology or developing technology for new or approved drugs, Callan has the formulation, synthetic, and intellectual property expertise to help.

Parenteral and Ophthalmic Drug Delivery

Solve complex drug delivery challenges related to:

  • Solubility
  • Bioavailability
  • Stability
Learn About Formulation Development

Lyophilization Services

We offer standard and complex lyophilization services and drug products:

  • Cycle design and refinement
  • Sealing and capping for 2 to 100 mL vial configurations
  • Co-solvent and nanoparticle self-assembly
Learn About Lyophilization

Intellectual Property

Full range of services to design, strategize, and building a strong IP portfolio, including:

  • Technology whitespace analysis
  • Designing around existing IP
  • Developing blocking IP
Learn More About IP
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Common problems (and how we fix them)

  1. Sterile Filtration Fails
    Symptoms: 0.22 µm clogging; slow filtration; yield loss
    Our Solutions: filterability as a gate for formulation development, prefilters, excipient tuning, viscosity control, and hold-time studies.
  2. Poor Drug Solubility
    Symptoms: can’t reach desired concentration; drug falls out of solution; storage temperature changes solubility
    Our Solutions: creative combinations of compendial excipients; eye on the future—evaluate if emerging technologies are enabling
  3. Painful Injections / Tolerability
    Symptoms: Sting; irritation at injection site; high injection force; clinical dropouts.
    Our Solutions: excipient swaps; shear/needle force modeling; depot/viscosifier; pH/tonicity/osmolality tuning.
  4. Poor PK / Exposure
    Symptoms: Low Cmax or AUC; short half-life; barrier-limited uptake (ocular or parenteral).
    Our Solutions: nanoparticle/lipid-based/polymer delivery platforms; controlled release formulations
  5. Expiring or Thin IP
    Symptoms: Easy to design around; 505(b)(2) risk; hard diligence questions; short IP runway after approval.
    Our Solutions: white-space mapping; diligence-ready documentation; patent specification drafting
  6. Scale-Up & Tech Transfer Problems
    Symptoms: CDMO can’t reproduce; unforeseen equipment restrictions; hold-time limitations
    Our Solutions: formulation design space studies; sterile filtration feasibility during formulation development; on-site help by our team

Partner with Callan Pharma

Callan Pharma provides its partners rapid, comprehensive and cost-effective solutions for their difficult formulation development projects.

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