Nanoparticle Formulations
Our founders have 30+ years of collective experience developing nanoparticle formulations to solve drug delivery challenges. We offer Practical, PK-minded nanoparticle systems for ophthalmic and injectable products
Small Molecule and Peptide Specialists
We specialize in the formulation of small molecule and peptides—especially the hydrophobic ones. We work with all shapes and sizes and find solutions for any drug delivery problem.
Small Molecule and Peptide Specialists
We specialize in the formulation of small molecule and peptides—especially the hydrophobic ones. We work with all shapes and sizes and find solutions for any drug delivery problem.
Micelles
Liposomes
Polymeric Nanoparticles
Lipid Nano Particles (LNPs)
Emulsions
Nanoparticles We Construct
- Micelles – effective carriers for hydrophobic APIs; high drug loading; PK modifying
- Liposomes – bilayer vehicles for solubility or depot/controlled release
- Polymeric Nanoparticles (PNPs) – tunable; biodegradable; strong IP creation possibilities
- Lipid Nanoparticles (LNPs): ionizable-lipid systems for select small molecules and peptides; proven record for injectables
- Emulsions: oil-in-water (O/W); water-in-oil (W/O); macro- and nano-emulsions; versatile for hydrophobic drugs
When Do Nanoparticles Make Sense
- Hydrophobic APIs that can’t meet target dose via standard excipients alone
- Need for exposure gains (AUC, Cmax) via retention or release-rate control
- Tolerability issues when using solvent-based formulations
- IP motivations: prospective white-space for composition of matter claims
FAQ’s
Do you always recommend nanoparticles?
No—if standard excipients & techniques meet goals, we avoid any unnecessary complexity.
Do you prefer using one type of nanoparticle over another?
No—the physiochemical properties of a drug and the desired property of the final drug product dictate our suggestions.
Can nanoparticles be used for topical ophthalmic drugs?
Yes—if the benefits of nanoparticles can be achieved while maintaining the tonicity, clarity, and low irritation needed.
Sterile filtration—is it possible for a nanoparticle product?
Yes—even if a sub-population of particles are above the pore size, a filtration process can be developed.
Partner with Callan Pharma
Callan Pharma provides its partners rapid, comprehensive and cost-effective solutions for their difficult formulation development projects.
