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Analytical Techniques for Injectable and Ophthalmic Formulations

Analytical Techniques Offered

We characterize nanoparticle systems, injectables, and ophthalmics for small molecules and peptides, and we test every formulation against the profile it has to hit: concentration, purity, particle size, stability, and filterability.

Gel permeation/Size exclusion Chromatography (GPC/SEC)

  • Size and polydispersity of polymers

Dynamic Light Scattering (DLS)

  • Size and polydispersity of nanoparticles

Ultra-performance liquid chromatography (UPLC)

  • Assay and purity of small molecules and peptides

Additional Analytical Techniques Offered

Callan Pharma Services has relationships with 3rd party vendors to perform additional analytical techniques. True pass-through costs are billed at cost, with no markup.

Gas Chromatography-Mass Spectrometry (GC-MS)

  • Residual solvent testing

Fourier-transform infrared spectroscopy (FT-IR)

  • Identification
  • Reaction monitoring

Microscopy

  • Particulate matter analysis

Routine Analytical Techniques Offered

Viscosity

  • Rotational viscometer
  • Viscosity is of particular importance for sub-Q delivery

Moisture

  • Karl Fischer
  • Critical parameter for lyophilized drug products

Osmolality

  • Vapor pressure osmometer
  • Necessary for parenteral and ophthalmic routes of delivery

Turbidity

  • Drug formulation stability indicator
  • Ophthalmic solutions
Instrumentation & Equipment
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Partner with Callan Pharma

Callan Pharma provides its partners rapid, comprehensive and cost-effective solutions for their difficult formulation development projects.

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