Formulation Techniques We Use
Ophthalmic and injectable formulations built with the right technique for the molecule—optimized for target concentration, sterile filterability, particle size, and clean tech transfer.
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Why the Choice of Formulation Technique Matters as Much as Excipients
Excipients set the what; the formulation technique determines the how—how it runs in manufacturing, holds up on stability, and performs in the clinic.
- Manufacturing: techniques fine tune particle/ droplet size, viscosity, scalability and filterability.
- Stability: incomplete removal of water or solvents, aggregation, and Oswald ripening are all a result of technique
- Clinical performance: particle/droplet size and viscosity directly impact administration tolerability and pharmacokinetics (e.g., release rate).
Techniques We Use
Technique selected for outcomes, not novelty—simple when possible, advanced when necessary.
Microfluidics
Applicable to highly crystalline APIs that need precise size control (e.g., polymeric micelles and liposomal).
Best for: tight PDI, tunable particle size.
We watch: shear and temperature, scalability, and particle properties
High-Shear Mixing / Homogenization
Simple and cost-effective high-energy mixing for uniform distribution of emulsions and nanoparticle systems.
Best for: emulsions, pre-mix for nanoparticle formulations, in particular polymeric and liposomal.
We watch: temperature, aeration, and shear-induced degradation.
Lyophilization-Enabled Nanoparticle Self-Assembly
Solvent-based lyophilization to generate self-assembling micelle & polymeric nanoparticle formulations upon reconstitution; useful for hydrophobic APIs, and drugs with shelf-stability challenges.
Best for: high loading with optical clarity, improved stability/shipping.
We watch: residual water & solvents, cake morphology, reconstitution time, and particle properties.
Emulsification
Uniform droplet formation via specialized mixing (including high-shear). Even dispersion for hydrophobic drugs; enables higher concentrations and improved pharmacokinetics.
Best for: ophthalmic (sub-micron) and injectable formulations within viscosity limitations.
We watch: uniformity, sterile filterability, and storage stability (e.g., Ostwald ripening).
Partner with Callan Pharma
Callan Pharma provides its partners rapid, comprehensive and cost-effective solutions for their difficult formulation development projects.
